The Detroit Lions and the Buffalo Bills meet Thursday for their Week 2 game in Orchard Park, New York. Kickoff is scheduled for 8:15 p.m. ET.

Heading into Week 2 of the 2026 NFL season, the Detroit Lions face another tough challenge, as the Buffalo Bills await Dan Campbell's squad. Detroit are currently 4.5-point underdogs against their AFC East opponent,

The Detroit Lions will be without two starting offensive linemen against the Buffalo Bills on Thursday night. Detroit ruled out rookie offensive tackle Blake Miller (knee) and guard Christian Mahogany (hip) with injuries.

Larry Hartstein reveals his picks for Detroit Lions vs. Buffalo Bills in the 2026 Week 2 'Thursday Night Football' matchup

The Jets return home for the first time in 2026 with a 1-0 record, but the Packers present a different challenge after a stunning Week 1 collapse.

Locked On Jets and Locked On Packers preview the Week 2 NFL matchup, discuss key players, and break down top storylines, matchups, and predictions.

After a painful loss to the Minnesota Vikings, the Green Bay Packers know they need to find a way to rebound when they head east to take on the New York Jets. FOX6 Sports Director Tim Van Vooren

Preview of Packers vs. Jets in NFL Week 2: 3 keys to a Green Bay win, matchup analysis, score prediction, and injury updates.

If you're located in the red area of the map, you'll see the Tennessee Titans and Philadelphia Eagles on your local FOX station.

The Tennessee Titans seek a rebound against the Philadelphia Eagles after a disappointing season opener loss to the New York Jets.

Tennessee Titans vs Philadelphia Eagles odds for NFL Week 2 game betting, including point spread, moneyline, over/under for Sunday, Sept. 20, 2026.

PHILADELPHIA − It sure seemed like the Eagles' new offense with the new blocking scheme and motions looked a lot like the old offense. And that was a problem. It could be again. The Eagles faced a defensive-minded head coach in Week 1 with the Commanders' Dan Quinn and escaped with a 24-22 win.

New York Giants quarterback Jaxson Dart had a brilliant showing in the team's Week 1 over the Dallas Cowboys, going 23-for-29 with 230 yards and three touchdowns while also adding 54 rushing yards. It was arguably the best performance of Dart's career,

The New York Giants got a convincing win against the Dallas Cowboys in Week 1, and many people are excited to see if they can keep this momentum going into the remainder of the season. They’ll have another big test in Week 2 against the Los Angeles Rams,

Giants coach John Harbaugh didn’t need to watch the tape of Sunday night’s massive win over the Cowboys to know how Jaxson Dart played. Dart — the Giants’ prized second-year quarterback — tore up Dallas’ still-rebuilding defense and put together the best game of his young career.

The Giants' 28-20 win over the Cowboys shook up leaguewide power rankings. Find out how they were rated by NFL pundits.

After a humiliating defeat to Grimsby Town in their previous League Cup campaign, Manchester United found a different way to exit the competition this time around. The jeers heard at the full-time whistle after throwing away a two-goal lead pointed to more worrying times a year on from Blundell Park.

Manchester United were beaten 3-2 by Brighton and Hove Albion in the Carabao Cup, with the Seagulls coming from two goals down to win the tie at Old Trafford

Michael Carrick took responsibility for Manchester United’s embarrassing Carabao Cup collapse to Brighton and demanded a reaction after his side were booed off the pitch at Old Trafford. An evening

Michael Carrick took responsibility for Manchester United's embarrassing League Cup collapse to Brighton and demanded a reaction after his side were booed off the pitch at Old Trafford. An evening that began with teenager Shea Lacey marking his first senior start with a dream goal and Mason Mount adding a second in the 10th minute ended in furious fans unloading at full-time.

The Buffalo Bills hired Joe Brady to replace Sean McDermott as their head coach, making Brady the NFL's youngest coach for 2026.

Brady took a minimalist approach the night before the Bills’ opener, but the first-year coach has his players' attention.

Bills & Joe Brady Pick Up Week 1 Win at Texans

Buffalo Bills head coach Joe Brady speaks during his press conference ahead of the home opener against the Detroit Lions on Thursday Night Football.